Acute toxicity studies, physicochemical and GC/MS analyses of Monodora myristica (Gaertn.) Dunal oil

Background: The seeds of Monodora myristica, a tropical plant belonging to the family Annonaceae, are widely used as condiments in preparation number African delicacies, impart or enhance flavour. Their use is largely due volatile and fixed oils contained nuts.Objective: To screen for acute toxicity (LD50) profile, determine physicochemical properties, well carry out GC-MS analysis seed oil myristica.Method: screening was done using Lorke’s method. Physicochemical profile determined standard methods. sample also carried out, Shimadzu GCMS-QP2010SE.Results: study showed that had an LD50 316 mg/kg. acid value be 9.27 mg KOH/g oil, while saponification 194.95 oil. revealed it fatty acids such n-hexadecanoic acid, cis-vaccenic 9,12-octadecadienoic acid; terpinoids alpha-terpineol alpha-cadinol.Conclusion: Results toxicological indicates myristica moderately toxic within 50 – 500 mg/kg range. has relatively high tendency go rancid